Statistical approach is a valuable way to describe texture primitives. The aim of this study is to design and implement a classifier framework to automatically identify the thyroid nodules from ultrasound images. Using rigorous mathematical foundations, this article focuses on developing a discriminative texture analysis method based on texture variations corresponding to four biological areas (normal thyroid, thyroid nodule, subcutaneous tissues, and trachea). Our research follows three steps: automatic extraction of the most discriminative first-order statistical texture features, building a classifier that automatically optimizes and selects the valuable features, and correlating significant texture parameters with the four biological areas of interest based on pixel classification and location characteristics. Twenty ultrasound images of normal thyroid and 20 that present thyroid nodules were used. The analysis involves both the whole thyroid ultrasound images and the region of interests (ROIs). The proposed system and the classification results are validated using the receiver operating characteristics which give a better overall view of the classification performance of methods. It is found that the proposed approach is capable of identifying thyroid nodules with a correct classification rate of 83 % when whole image is analyzed and with a percent of 91 % when the ROIs are analyzed.