Pluronic F108 coating decreases the lung fibrosis potential of multiwall carbon nanotubes by reducing lysosomal injury

Nano Lett. 2012 Jun 13;12(6):3050-61. doi: 10.1021/nl300895y. Epub 2012 May 4.

Abstract

We compared the use of bovine serum albumin (BSA) and pluronic F108 (PF108) as dispersants for multiwalled carbon nanotubes (MWCNTs) in terms of tube stability as well as profibrogenic effects in vitro and in vivo. While BSA-dispersed tubes were a potent inducer of pulmonary fibrosis, PF108 coating protected the tubes from damaging the lysosomal membrane and initiating a sequence of cooperative cellular events that play a role in the pathogenesis of pulmonary fibrosis. Our results suggest that PF108 coating could serve as a safer design approach for MWCNTs.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Administration, Inhalation
  • Animals
  • Coated Materials, Biocompatible / chemistry*
  • Lysosomes / drug effects*
  • Lysosomes / pathology*
  • Mice
  • Nanotubes, Carbon / toxicity*
  • Poloxamer / chemistry*
  • Pulmonary Fibrosis / chemically induced*
  • Pulmonary Fibrosis / pathology
  • Pulmonary Fibrosis / prevention & control*

Substances

  • Coated Materials, Biocompatible
  • Nanotubes, Carbon
  • Poloxamer