A new investigation for some steroidal derivatives as anti-Alzheimer agents

Int J Biol Macromol. 2012 Jul-Aug;51(1-2):56-63. doi: 10.1016/j.ijbiomac.2012.04.012. Epub 2012 Apr 20.

Abstract

We herein report the anti-Alzheimer activity of some synthesized heterocyclic pyrimidine and thiopyrimidine derivatives fused with steroidal structure. Twenty-one of these compounds were synthesized and conveniently screened for their anti-Alzheimer activities using of Flurbiprofen as the reference drug. Some of these compounds were demonstrated to exhibit remarkable activity and their β-amyloid (Aβ) lowering results as IC(50) values reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / metabolism
  • Amyloid beta-Peptides / metabolism
  • Animals
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology
  • Cell Line
  • Cyclooxygenase Inhibitors / chemistry
  • Cyclooxygenase Inhibitors / pharmacology
  • Female
  • Heterocyclic Compounds / chemistry
  • Heterocyclic Compounds / pharmacology
  • Humans
  • Inhibitory Concentration 50
  • Male
  • Mice
  • Mice, Transgenic
  • Pyrimidines / chemical synthesis
  • Pyrimidines / chemistry*
  • Pyrimidines / pharmacology*
  • Steroids / chemical synthesis
  • Steroids / chemistry*
  • Steroids / pharmacology*
  • Structure-Activity Relationship

Substances

  • Amyloid beta-Peptides
  • Anti-Inflammatory Agents
  • Cyclooxygenase Inhibitors
  • Heterocyclic Compounds
  • Pyrimidines
  • Steroids