The association studies of ADIPOQ with type 2 diabetes mellitus in Chinese populations

Diabetes Metab Res Rev. 2012 Oct;28(7):551-9. doi: 10.1002/dmrr.2309.

Abstract

Adiponectin, which is secreted by the white adipose tissue, plays an important role in type 2 diabetes mellitus (T2DM) and its complications. Since 2002, many investigators explored the association between ADIPOQ single nucleotide polymorphisms and T2DM in different ethnic populations from different regions. In China, the results of numerous studies of the association between ADIPOQ and T2DM were not consistent, which may be caused by population-specific effects or environmental effects. This review describes the association between ADIPOQ and T2DM, the metabolic characteristics and the complications of T2DM in Chinese populations.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adiponectin / genetics*
  • Adiponectin / metabolism
  • China
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / genetics*
  • Diabetes Mellitus, Type 2 / metabolism
  • Genetic Association Studies
  • Humans
  • Mutation
  • Polymorphism, Single Nucleotide*

Substances

  • ADIPOQ protein, human
  • Adiponectin