Burkitt lymphoma in a child with atopic dermatitis and a 7-year history of regular topical tacrolimus use

Cutis. 2012 Mar;89(3):117-20.

Abstract

We describe the case of a boy who presented with abdominal Burkitt lymphoma; he had been regularly using tacrolimus ointment 0.1% for severe recurrent atopic dermatitis for 7 years immediately prior to developing cancer. We present his medical history and review the current knowledge regarding a link between topical tacrolimus and malignancy risk.

Publication types

  • Case Reports

MeSH terms

  • Administration, Cutaneous
  • Burkitt Lymphoma / chemically induced
  • Burkitt Lymphoma / complications
  • Burkitt Lymphoma / diagnosis*
  • Burkitt Lymphoma / surgery
  • Child
  • Dermatitis, Atopic / complications
  • Dermatitis, Atopic / drug therapy*
  • Diagnosis, Differential
  • Humans
  • Ileal Diseases / complications
  • Ileal Diseases / diagnosis
  • Ileal Diseases / surgery
  • Ileal Neoplasms / chemically induced
  • Ileal Neoplasms / complications
  • Ileal Neoplasms / diagnosis*
  • Ileal Neoplasms / surgery
  • Ileocecal Valve* / surgery
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / adverse effects*
  • Intussusception / complications
  • Intussusception / diagnosis
  • Intussusception / surgery
  • Male
  • Tacrolimus / administration & dosage
  • Tacrolimus / adverse effects*
  • Tomography, X-Ray Computed

Substances

  • Immunosuppressive Agents
  • Tacrolimus