Ianthellamide A, a selective kynurenine-3-hydroxylase inhibitor from the Australian marine sponge Ianthella quadrangulata

Yunjiang Feng; Bruce F Bowden; Vimal Kapoor

doi:10.1016/j.bmcl.2012.04.002

Ianthellamide A, a selective kynurenine-3-hydroxylase inhibitor from the Australian marine sponge Ianthella quadrangulata

Bioorg Med Chem Lett. 2012 May 15;22(10):3398-401. doi: 10.1016/j.bmcl.2012.04.002. Epub 2012 Apr 7.

Authors

Yunjiang Feng¹, Bruce F Bowden, Vimal Kapoor

Affiliation

¹ Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia. y.feng@griffith.edu.au

PMID: 22525315
DOI: 10.1016/j.bmcl.2012.04.002

Abstract

Ianthellamide A (1), a novel octopamine derivative, was isolated from the Australian marine sponge Ianthella quadrangulata. Compound 1 selectively inhibited the activity of kynurenine 3-hydroxylase with an IC(50) value of 1.5 μM. It also significantly increased the level of endogenous kynurenic acid in rat brain and hence has the potential as a neuroprotective agent in the treatment of neurodegenerative disorders.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Benzenesulfonates / pharmacology*
Enzyme Inhibitors / pharmacology*
Inhibitory Concentration 50
Kynurenine 3-Monooxygenase / antagonists & inhibitors*
Magnetic Resonance Spectroscopy
Marine Biology
Octopamine / analogs & derivatives*
Octopamine / pharmacology
Porifera / chemistry*

Substances

Benzenesulfonates
Enzyme Inhibitors
lanthellamide A
Octopamine
Kynurenine 3-Monooxygenase