Abstract
Neuroendocrine carcinoma (NEC) of the anal canal is exceedingly rare and its histogenesis is poorly understood. We present a case of small-cell NEC of the anal canal in a 70-year-old woman. The NEC appeared as a submucosal tumor at the dentate line and was associated with squamous intraepithelial neoplasia (SIN). The NEC was positive for neuroendocrine markers including synaptophysin, chromogranin A and CD56, whereas the SIN component did not express any of these markers. Both components exhibited p16 overexpression. A PCR analysis revealed that both the SIN and NEC components were positive for human papillomavirus (HPV) 18 DNA. Our observations imply that SIN may be a precursor of anal canal NEC and that HPV18 may play an important role in the histogenesis of anal canal NEC, similar to its role in cervical NEC.
© 2012 The Authors. Pathology International © 2012 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Anus Neoplasms / metabolism
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Anus Neoplasms / pathology*
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Anus Neoplasms / virology
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Biomarkers, Tumor / metabolism
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Bone Neoplasms / secondary
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Carcinoma in Situ / metabolism
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Carcinoma in Situ / pathology*
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Carcinoma in Situ / virology
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Carcinoma, Neuroendocrine / metabolism
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Carcinoma, Neuroendocrine / secondary*
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Carcinoma, Neuroendocrine / virology
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Carcinoma, Squamous Cell / metabolism
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Carcinoma, Squamous Cell / secondary*
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Carcinoma, Squamous Cell / virology
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DNA, Viral / genetics
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Fatal Outcome
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Female
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HeLa Cells
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Human papillomavirus 18 / genetics
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Human papillomavirus 18 / isolation & purification*
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Humans
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Immunohistochemistry
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Lung Neoplasms / secondary
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Neoplasm Proteins / metabolism
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Neoplasms, Multiple Primary
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Papillomavirus Infections / metabolism
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Papillomavirus Infections / pathology*
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Papillomavirus Infections / virology
Substances
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Biomarkers, Tumor
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DNA, Viral
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Neoplasm Proteins