Abstract
A series of 4-methylcoumarin derivatives containing 4,5-dihydropyrazole moiety were synthesized and their antioxidant activities were evaluated in AAPH (2,2'-azobis(2-amidinopropane hydrochloride))-induced oxidation of DNA, and in trapping DPPH (2,2'-diphenyl-1-picrylhydrazyl) and ABTS(+•) (2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) cationic radical), respectively. Among coumarin derivatives, 3a-d and 4a-c exhibited the termination of radical propagation-chains in AAPH-induced oxidation of DNA. The ortho dihydroxyphenyl substitution at 5 position and 1-unsubstitution of the 4,5-dihydroxylpyrazole was found enhancing the antioxidant activities of these coumarin derivatives.
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amidines / pharmacology
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Benzothiazoles / chemistry
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Biphenyl Compounds / chemistry
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Chemistry Techniques, Synthetic
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Coumarins / chemical synthesis*
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Coumarins / chemistry
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Coumarins / pharmacology*
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DNA / metabolism*
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Free Radical Scavengers / chemical synthesis*
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / pharmacology*
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Oxidation-Reduction / drug effects
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Picrates / chemistry
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Pyrazoles / chemistry*
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Sulfonic Acids / chemistry
Substances
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Amidines
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Benzothiazoles
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Biphenyl Compounds
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Coumarins
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Free Radical Scavengers
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Picrates
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Pyrazoles
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Sulfonic Acids
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2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
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2,2'-azobis(2-amidinopropane)
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DNA
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1,1-diphenyl-2-picrylhydrazyl