Guanacastane-type diterpenoids from Coprinus radians

Yi-xin Ou; Yao-yao Li; Xiao-ming Qian; Yue-mao Shen

doi:10.1016/j.phytochem.2012.03.002

Guanacastane-type diterpenoids from Coprinus radians

Phytochemistry. 2012 Jun:78:190-6. doi: 10.1016/j.phytochem.2012.03.002. Epub 2012 Apr 19.

Authors

Yi-xin Ou¹, Yao-yao Li, Xiao-ming Qian, Yue-mao Shen

Affiliation

¹ Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen, Fujian 361005, PR China.

PMID: 22521133
DOI: 10.1016/j.phytochem.2012.03.002

Abstract

Thirteen diterpenoids, named radianspenes A-M (1-13), including three lactams radianspenes J (10), K (11) and L (12) and one dimer radianspene M (13), were isolated from fermentation products of the higher fungal strain Coprinus radians M65. All these compounds possessing guanacastane skeleton were evaluated for antitumor activity using MDA-MB-435 cell line. Radianspene C exhibited inhibitory activity with IC(50) of 0.91 μM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology
Coprinus / chemistry*
Diterpenes / chemistry
Diterpenes / classification
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Drug Screening Assays, Antitumor
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular

Substances

Antineoplastic Agents, Phytogenic
Diterpenes