Antinociceptive and anti-inflammatory activity of the ethanolic extract of Cymbidium aloifolium (L.)

Pak J Biol Sci. 2011 Oct 1;14(19):909-11. doi: 10.3923/pjbs.2011.909.911.

Abstract

The ethanol leaf extract of Cymbidium aloifolium (L.) was evaluated for its analgesic and antiinflammatory activities. The extract, at the dose of 200 and 400 mg kg(-1) body weight, exerted the analgesic activity by observing the number of abdominal contractions and anti-inflammatory activity against Carrageenin induced paw edema in mice by measuring the paw volume. The ethanolic extract of Cymbidium aloifolium (L.) showed statistically significant (p < 0.05) reduction of percentage of writhing of 33.57 and 61.31% at 200 and 400 mg kg(-1) oral dose, respectively, when compared to negative control. The Ethanolic plant extract also showed significant (p < 0.05) dose dependent reduction of mean increase of formation of paw edema. The results of the experiment and its statistical analysis showed that the ethanolic plant extract had shown significant (p < 0.05) dose dependent analgesic and anti-inflammatory activities when compared to the control.

MeSH terms

  • Acetic Acid / adverse effects
  • Analgesics / chemistry*
  • Analgesics / pharmacology*
  • Animals
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / pharmacology*
  • Carrageenan
  • Edema / chemically induced
  • Edema / drug therapy
  • Ethanol / chemistry*
  • Female
  • Male
  • Mice
  • Pain Measurement / drug effects
  • Pain Measurement / methods
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology*
  • Plant Leaves / chemistry

Substances

  • Analgesics
  • Anti-Inflammatory Agents
  • Plant Extracts
  • Ethanol
  • Carrageenan
  • Acetic Acid