Abstract
Abscisic acid (ABA) is an essential hormone that controls plant growth, development and responses to abiotic stresses. ABA signaling is mediated by type 2C protein phosphatases (PP2Cs), including HAB1 and ABI2, which inhibit stress-activated SnRK2 kinases and whose activity is regulated by ABA and ABA receptors. Based on biochemical data and our previously determined crystal structures of ABI2 and the SnRK2.6-HAB1 complex, we present the catalytic mechanism of PP2C and provide new insight into PP2C-SnRK2 interactions and possible roles of other SnRK2 kinases in ABA signaling.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Abscisic Acid / metabolism*
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Amino Acid Sequence
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Arabidopsis / chemistry
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Arabidopsis / metabolism*
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Arabidopsis Proteins / chemistry
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Arabidopsis Proteins / metabolism*
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Molecular Sequence Data
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Multiprotein Complexes / chemistry
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Multiprotein Complexes / metabolism*
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Phosphoprotein Phosphatases / chemistry
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Phosphoprotein Phosphatases / metabolism*
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Plant Growth Regulators / metabolism*
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Protein Phosphatase 2C
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Protein Serine-Threonine Kinases / chemistry
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Protein Serine-Threonine Kinases / metabolism*
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Signal Transduction
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Stress, Physiological
Substances
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Arabidopsis Proteins
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Multiprotein Complexes
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Plant Growth Regulators
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SnRK2 protein, Arabidopsis
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Abscisic Acid
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Protein Serine-Threonine Kinases
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ABI2 protein, Arabidopsis
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HAB1 protein, Arabidopsis
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Phosphoprotein Phosphatases
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Protein Phosphatase 2C