Rhodium-catalyzed oxidative C2-acylation of indoles with aryl and alkyl aldehydes

Chem Commun (Camb). 2012 May 25;48(42):5163-5. doi: 10.1039/c2cc31351k. Epub 2012 Apr 19.

Abstract

A rhodium-catalyzed oxidative C2-acylation of indoles with aryl and alkyl aldehydes via C-H bond activation is described. The reaction is highly atom-economic and provides easy access to a wide variety of 2-aroylindoles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acylation
  • Aldehydes / chemistry*
  • Alkenes / chemistry
  • Alkynes / chemistry
  • Carbon / chemistry
  • Catalysis
  • Indoles / chemistry*
  • Oxidation-Reduction
  • Rhodium / chemistry*

Substances

  • Aldehydes
  • Alkenes
  • Alkynes
  • Indoles
  • Carbon
  • Rhodium