Abstract
Objective:
To investigate the neuroprotective effect of ferulic acid on PC12 cells injuries.
Methods:
With three models of PC12 cells injured by hypoxia, excitatory amino acids (EAA) and radical, the effect of ferulic acid on injured PC12 cells was observed by MTT assay.
Results:
Compared with three models, ferulic acid (1-100 micromol/L) could promote cell viability notably (P<0.05 or P<0.01).
Conclusion:
Ferulic acid has notable protective effect on PC12 cells injured by hypoxia, EAA and radical.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Hypoxia
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Cell Proliferation / drug effects
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Coumaric Acids / pharmacology*
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Dementia, Vascular / prevention & control*
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Free Radical Scavengers / pharmacology*
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Glutamic Acid / metabolism
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Hydrogen Peroxide / metabolism
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Neuroprotective Agents / pharmacology*
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PC12 Cells
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Plants, Medicinal / chemistry
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Rats
Substances
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Coumaric Acids
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Free Radical Scavengers
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Neuroprotective Agents
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Glutamic Acid
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ferulic acid
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Hydrogen Peroxide