Remission in early rheumatoid arthritis -- a comparison of new ACR/EULAR remission criteria to established criteria

J Rheumatol. 2012 Jun;39(6):1155-8. doi: 10.3899/jrheum.111341. Epub 2012 Apr 15.

Abstract

Objective: To describe the frequency of remission in an early rheumatoid arthritis (ERA) cohort.

Methods: The frequency of remission was evaluated, based on 8 definitions including the Boolean-based American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria.

Results: Of 369 patients, remission at 12 months ranged from 18% according to the ACR/EULAR clinical trial criteria to 40% according to the 28-joint Disease Activity Score (DAS28) < 2.6. Higher tender joint count, swollen joint count, and physician global scores were seen for DAS28-based definitions, and patient global assessment (PtGA) scores were almost 5-fold higher for DAS28 remission.

Conclusion: Remission is achievable in ERA but its frequency differs according to the remission definition applied. Adoption of the new ACR/EULAR definition will limit the number classified as in remission, especially if the PtGA criteria are rated high for reasons other than inflammatory arthritis.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antirheumatic Agents / therapeutic use*
  • Arthritis, Rheumatoid / diagnosis*
  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / physiopathology
  • Cohort Studies
  • Disease Progression
  • Drug Therapy, Combination
  • Early Diagnosis
  • Female
  • Humans
  • Joints / drug effects
  • Joints / pathology
  • Joints / physiopathology
  • Male
  • Middle Aged
  • Outcome Assessment, Health Care / methods*
  • Remission Induction
  • Reproducibility of Results

Substances

  • Antirheumatic Agents