Abstract
We report on seizures during anesthesia induction in animals treated with a cannabinoid receptor 1 (CB1R) antagonist for experimental sepsis. Animals received surgery for colon ascendens stent peritonitis-induced sepsis or sham surgery followed by treatment of CB1R antagonist, CB1R agonist, or placebo. Fourteen hours later, animals received pentobarbital or ketamine for anesthesia induction and animal behavior was observed. Tonic-clonic seizures were observed in 5 of 12 septic animals (42%) treated with CB1R antagonist after induction of anesthesia with pentobarbital. The data suggest that CB1R inhibition in combination with pentobarbital may increase the incidence of anesthetic-induced seizures in the case of sepsis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anesthesia / adverse effects*
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Animals
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Arachidonic Acids / pharmacology
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Behavior, Animal / drug effects
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Disease Models, Animal
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Epilepsy, Tonic-Clonic / etiology*
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Epilepsy, Tonic-Clonic / metabolism
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Epilepsy, Tonic-Clonic / psychology
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Hypnotics and Sedatives / toxicity*
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Male
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Morpholines / toxicity*
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Pentobarbital / toxicity*
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Pyrazoles / toxicity*
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Rats
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Rats, Inbred Lew
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Receptor, Cannabinoid, CB1 / agonists
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Receptor, Cannabinoid, CB1 / antagonists & inhibitors*
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Receptor, Cannabinoid, CB1 / metabolism
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Sepsis / complications*
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Sepsis / drug therapy*
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Sepsis / metabolism
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Time Factors
Substances
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Arachidonic Acids
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Cnr1 protein, rat
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Hypnotics and Sedatives
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Morpholines
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Pyrazoles
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Receptor, Cannabinoid, CB1
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arachidonyl-2-chloroethylamide
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Pentobarbital
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AM 281