A multicomponent formal [1+2+1+2]-cycloaddition for the synthesis of dihydropyridines

P Ricardo Girling; Andrei S Batsanov; Hong C Shen; Andrew Whiting

doi:10.1039/c2cc31495a

A multicomponent formal [1+2+1+2]-cycloaddition for the synthesis of dihydropyridines

Chem Commun (Camb). 2012 May 18;48(40):4893-5. doi: 10.1039/c2cc31495a. Epub 2012 Apr 13.

Authors

P Ricardo Girling¹, Andrei S Batsanov, Hong C Shen, Andrew Whiting

Affiliation

¹ Centre for Sustainable Chemical Processes, Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.

PMID: 22499258
DOI: 10.1039/c2cc31495a

Abstract

Reaction of methoxyvinylmethylketone with different amines and aldehydes under Lewis-acid catalysed conditions results in a novel, formal, step-wise [1+2+1+2]-cycloaddition to give dihydropyridine products.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehydes / chemistry
Amines / chemistry
Catalysis
Crystallography, X-Ray
Cyclization
Dihydropyridines / chemical synthesis*
Dihydropyridines / chemistry
Lewis Acids / chemistry
Molecular Conformation

Substances

Aldehydes
Amines
Dihydropyridines
Lewis Acids