Intraocular inflammation/uveitis is one of the more poorly understood areas in the field of ophthalmology. We hope to improve this understanding by first reviewing the classic histopathologic approach to intraocular inflammation, and then by integrating that with the current role of histopathology in the diagnosis and management of uveitis. Herein, we will present a systematic approach, beginning with the most accessible conjunctival, lacrimal gland and lymph node biopsy sites; extending through anterior chamber tap, iris biopsy, and vitrectomy and ending with retinal or chorioretinal biopsy of distant organ sites. We will show how a combination of these histopathologic elements can aid in the diagnosis, and thereby the management, of intraocular inflammations and uveitis.