Abstract
The aim of this work was to prepare L- and D-(adamant-1-yl)-Gly-L-Ala-D-isoGln peptides in order to study their adjuvant (immunostimulating) activities. Adjuvant activity of adamant-1-yl tripeptides was tested in the mouse model using ovalbumin as an antigen and in comparison to the peptidoglycan monomer (PGM; β-D-GlcNAc-(1→4)-D-MurNAc-L-Ala-D-isoGln-mesoDAP(εNH(2) )-D-Ala-D-Ala) and structurally related adamant-2-yl tripeptides.
Copyright © 2012 Verlag Helvetica Chimica Acta AG, Zürich.
MeSH terms
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Adamantane / analogs & derivatives*
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Adamantane / chemical synthesis
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Adamantane / pharmacology*
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Adjuvants, Immunologic / chemical synthesis
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Adjuvants, Immunologic / chemistry*
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Adjuvants, Immunologic / pharmacology*
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Animals
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Mice
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Oligopeptides / chemical synthesis
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Oligopeptides / chemistry*
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Oligopeptides / pharmacology*
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Ovalbumin / immunology
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Peptidoglycan / chemistry
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Peptidoglycan / pharmacology
Substances
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Adjuvants, Immunologic
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Oligopeptides
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Peptidoglycan
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Ovalbumin
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Adamantane