Objective: Through determine the copper content of decidua, chorion and blood serum of first pregnancy women with Cu-IUD, we offer date for security of offspring.
Methods: March 2010 to December 2010, in family planning clinics of the general hospital of Tianjin medical university, we selected twenty-five first pregnancy women with Cu-IUD who intended to terminate pregnancy to be experimental group and twenty-five normal first pregnancy women who intended to terminate pregnancy to be control group, and determined the copper content of decidua, chorion and blood serum in experimental group and control group.
Results: The copper content of decidua, chorion and blood serum in experimental group is (0.91 ± 0.51) mg/kg, (0.72 ± 0.50) mg/kg, (0.79 ± 0.15) mg/L; the copper content of decidua, chorion and blood serum in control group is (0.57 ± 0.21) mg/kg, (0.46 ± 0.21) mg/kg, (0.71 ± 0.15) mg/L. The copper content of blood serum has no significant difference between experimental group and control group (P > 0.05). The copper content of decidua, chorion of experimental group is higher than control group (P < 0.05).
Conclusion: Copper ion released from Cu-IUD only has an influence on the uterus tissues, but having no influence on the copper metabolism all over the body. The effects of high copper content of chorion in first pregnancy women with Cu-IUD on the offspring security will be researched further.