Objective: To explore the variance of mean platelet volume (MPV) in subjects with normal glucose tolerance (NGT), impaired glucose regulation (IGR) and type 2 diabetes mellitus (T2DM) and risk factors of MPV changes and analyze the relationship between MPV and diabetic peripheral artery disease (PAD).
Methods: A total of 173 subjects were enrolled into this observational cross-sectional study. They were divided into 3 groups: NGT (n = 41), IGR (n = 41) and T2DM (n = 91). Blood pressure (BP), platelet count (PLT), mean platelet volume (MPV) and such fasting serum lipids as triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), fast plasma glucose (FPG) and serum uric acid (UA) were determined. HbA1c and ankle/brachial index (ABI) were also measured.
Results: (1) The MPV level was highest in the T2DM group (12.3 ± 1.5) fl. And it was significantly higher in the IGR group than in the NGT group (9.7 ± 0.9 vs 8.0 ± 0.9) fl (P < 0.01). It was significantly higher in diabetics with HbA1c ≥ 7% (13.2 ± 1.9) fl than in patients those with HbA1c 7% (11.8 ± 1.7) fl (P < 0.01); (2) Stepwise multiple regression analysis showed that age, serum creatinine, LDL-C and fasting plasma glucose (FPG) were important influencing factors of MPV (adjusted R(2) = 0.891); (3) Multiple Logistic regression analysis indicated that MPV was an important risk factor of PAD.
Conclusion: The MPV level in T2DM is significantly higher than that in NGT and IGR subjects. FPG, LDL-C, age and serum creatinine are important contributors to MPV. And MPV is an important risk factor of PAD.