Biocompatible zwitterionic sulfobetaine copolymer-coated mesoporous silica nanoparticles for temperature-responsive drug release

Macromol Rapid Commun. 2012 May 14;33(9):811-8. doi: 10.1002/marc.201100876. Epub 2012 Apr 5.

Abstract

A novel nanocontainer, which could regulate the release of payloads, has been successfully fabricated by attaching zwitterionic sulfobetaine copolymer onto the mesoporous silica nanoparticles (MSNs). RAFT polymerization is employed to prepare the hybrid poly(2-(dimethylamino)ethyl methacrylate)-coated MSNs (MSN-PDMAEMA). Subsequently, the tertiary amine groups in PDMAEMA are quaternized with 1,3-propanesultone to get poly(DMAEMA-co-3-dimethyl(methacryloyloxyethyl)ammonium propanesulfonate)-coated MSNs [MSN-Poly(DMAEMA-co-DMAPS)]. The zwitterionic PDMAPS component endows the nanocarrier with biocompatibility, and the PDMAEMA component makes the copolymer shell temperature-responsive. Controlled release of loaded rhodamine B has been achieved in the saline solutions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Betaine / analogs & derivatives*
  • Betaine / chemical synthesis*
  • Betaine / chemistry
  • Betaine / toxicity
  • Cell Survival / drug effects
  • Delayed-Action Preparations
  • Drug Delivery Systems
  • HeLa Cells
  • Humans
  • Methacrylates / chemistry
  • Nanocapsules / chemistry*
  • Nanocapsules / toxicity
  • Nanocapsules / ultrastructure
  • Nylons / chemistry
  • Polymerization
  • Polymethacrylic Acids / chemical synthesis*
  • Polymethacrylic Acids / chemistry
  • Polymethacrylic Acids / toxicity
  • Rhodamines / chemistry
  • Silicon Dioxide / chemistry*
  • Spectroscopy, Fourier Transform Infrared
  • Temperature

Substances

  • Delayed-Action Preparations
  • Methacrylates
  • Nanocapsules
  • Nylons
  • Polymethacrylic Acids
  • Rhodamines
  • poly(2-(dimethylamino)ethyl methacrylate)
  • Betaine
  • Silicon Dioxide
  • sulfobetaine
  • rhodamine B