Abstract
A new steroid, itesmol 3-O-palmitate (1), along with two known steroids were isolated from the trunk of Berberis koreana. The structure of 1 was determined on the basis of spectroscopic analyses involving 2D NMR and chemical reactions. Compound 1 exhibited potential antiproliferative activity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines (respective IC(50) values of 7.41, 9.20, 4.53, and 12.91 µM).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Berberis / chemistry*
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Humans
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Palmitates / chemistry
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Palmitates / isolation & purification*
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Palmitates / pharmacology
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification*
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Plant Extracts / pharmacology
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Steroids / chemistry
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Steroids / isolation & purification*
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Steroids / pharmacology
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Stigmasterol / analogs & derivatives*
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Stigmasterol / chemistry
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Stigmasterol / isolation & purification
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Stigmasterol / pharmacology
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Wood / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Palmitates
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Plant Extracts
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Steroids
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itesmol 3-O-palmitate
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Stigmasterol