Specific complications of sickle cell disease (SCD) may emerge during adolescence, and education of patients and families is vital during transition from paediatric to adult health care. Adolescents with SCD have to adjust to the constraints of living with a lifelong chronic condition, and compliance with self-care and medical treatments can be problematic. This article explores potential opportunities for intervention, and examines how the role of the adolescent clinical nurse specialist is pivotal in supporting patients and families during this transition.