Human Immune Deficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS) has posed different set of challenges towards the country's growth and has also changed the strategic approach of Public Health for containing the further growth of the disease. HIV/AIDS is considered as more of a social problem than a medical problem alone. National AIDS Control Program (NACP) though its three phases have tried to design & implement evidence based strategies including Targeted Interventions (TI) based on the lessons learnt in the past. It has been a long journey for more than a decade which has brought innovations & effectiveness into the program and is showing some preliminary results in positive direction in limiting the HIV infection among HRGs. In the present communication few of the salient features of the entire approach and possible impacts in the future have been discussed.