Abstract
Female rhesus macaques were immunized with HIV virus-like particles (HIV-VLPs) or HIV DNA administered as sequential combinations of mucosal (intranasal) and systemic (intramuscular) routes, according to homologous or heterologous prime-boost schedules. The results show that in rhesus macaques only the sequential intranasal and intramuscular administration of HIV-VLPs, and not the intranasal alone, is able to elicit humoral immune response at the systemic as well as the vaginal level.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS Vaccines / administration & dosage*
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AIDS Vaccines / immunology*
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Administration, Intranasal
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Animals
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Blood / immunology
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Female
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HIV / immunology*
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HIV Antibodies / analysis
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HIV Antibodies / blood
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Injections, Intramuscular
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Macaca mulatta
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Vaccination / methods
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Vaccines, DNA / administration & dosage*
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Vaccines, DNA / immunology*
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Vaccines, Virosome / administration & dosage
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Vaccines, Virosome / immunology
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Vagina / immunology
Substances
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AIDS Vaccines
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HIV Antibodies
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Vaccines, DNA
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Vaccines, Virosome