Abstract
TNF-α-inducing protein (Tipα) is a unique carcinogenic factor of Helicobacter pylori, which is secreted into culture broth. The biological activities of Tipα and deletion mutant were studied. Tipα protein specifically binds to cell-surface nucleolin and then enters the gastric cancer cells, where TNF-α and chemokine gene expressions are induced by NF-κB activation. Nucleolin localizes on the surface of gastric cancer cells, and interaction between Tipα and cell-surface nucleolin causes a cancer-oriented microenvironment that increases the risk of gastric cancer. This paper discusses a new mechanism of gastric cancer development with H. pylori and provides a new preventive strategy.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Bacterial Proteins / antagonists & inhibitors
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Bacterial Proteins / chemistry
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Bacterial Proteins / metabolism*
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Cell Transformation, Neoplastic
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Chemokines / genetics
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Gene Expression
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Humans
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Molecular Sequence Data
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Molecular Targeted Therapy
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NF-kappa B / metabolism
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Nucleolin
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Phosphoproteins / antagonists & inhibitors
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Phosphoproteins / metabolism
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Protein Binding
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Protein Structure, Tertiary
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RNA-Binding Proteins / antagonists & inhibitors
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RNA-Binding Proteins / metabolism
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Stomach Neoplasms / etiology*
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Stomach Neoplasms / metabolism
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Stomach Neoplasms / therapy
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Tumor Necrosis Factor-alpha / genetics
Substances
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Bacterial Proteins
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Chemokines
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NF-kappa B
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Phosphoproteins
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RNA-Binding Proteins
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Tipalpha protein, Helicobacter pylori
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Tumor Necrosis Factor-alpha