Abstract
Specific mutations within the hypervariable herpes simplex virus (HSV) gene thymidine kinase (TK) gene lead to acyclovir (ACV) resistance. To uncover the existence of latent ACV-resistant (ACV(R)) HSV-1, we determined the genetic and functional variability of the HSV-1 TK gene pool in paired trigeminal ganglia (TG) of 5 immunocompetent individuals. The latent virus pool consisted of a donor-specific HSV-1 quasispecies, including one major ACV-sensitive (ACV(S)) and multiple phylogenetic-related minor ACV(S) and ACV(R) TK variants. Contrary to minor variants, major TK variants were shared between paired TG. The data demonstrate the coexistence of phylogenetic-related ACV(S) and ACV(R) latent HSV-1 in human TG.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acyclovir / pharmacology*
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Aged
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Aged, 80 and over
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Animals
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Antiviral Agents / pharmacology*
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Autopsy
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Base Sequence
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COS Cells
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Chlorocebus aethiops
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DNA, Viral / genetics
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Drug Resistance, Viral / genetics
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Female
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Herpes Simplex / drug therapy
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Herpes Simplex / virology*
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Herpesvirus 1, Human / drug effects
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Herpesvirus 1, Human / genetics*
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Herpesvirus 1, Human / physiology
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Humans
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Immunocompetence
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Male
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Molecular Sequence Data
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Mutation
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Phylogeny
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Prevalence
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Sequence Analysis, DNA
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Thymidine Kinase / chemistry
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Thymidine Kinase / genetics*
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Thymidine Kinase / metabolism
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Trigeminal Ganglion / virology*
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Virus Latency
Substances
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Antiviral Agents
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DNA, Viral
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Thymidine Kinase
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Acyclovir
Associated data
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GENBANK/HQ667768
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