Immunomodulatory efficiency of poly(2-oxazolines)

J Mater Sci Mater Med. 2012 Jun;23(6):1457-64. doi: 10.1007/s10856-012-4621-7. Epub 2012 Mar 29.

Abstract

Poly(2-oxazolines) represent promising polymer materials for biomedical applications. The activation of mouse lymphoid macrophage line P388.D1 (clone 3124) by two selected representatives of poly(2-oxazolines), namely poly(2-ethyl-2-oxazoline) (PETOX100) and poly[2-(4-aminophenyl)-2-oxazoline-co-2-ethyl-2-oxazoline] (AEOX10), was assessed in vitro. The immunomodulatory efficacy of both polymers was evaluated via the induced release of pro-inflammatory cytokines (TNF-α, IL-1α and IL-6) and the acceleration of reactive free radicals. The present study revealed effective structure-immunomodulating associations of AEOX10 and PETOX100, which are desirable in biomedical and pharmaceutical applications of aliphatic and aromatic poly (2-oxazolines) in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / pharmacology*
  • Cell Line
  • Immunologic Factors / chemistry
  • Immunologic Factors / pharmacology*
  • Interleukin-1alpha / biosynthesis
  • Interleukin-6 / biosynthesis
  • Macrophage Activation / drug effects
  • Magnetic Resonance Spectroscopy
  • Materials Testing
  • Mice
  • Oxazoles / chemistry
  • Oxazoles / pharmacology
  • Polyamines / chemistry
  • Polyamines / pharmacology*
  • Reactive Oxygen Species / metabolism
  • Spectroscopy, Fourier Transform Infrared
  • Tumor Necrosis Factor-alpha / biosynthesis

Substances

  • 2-(4-aminophenyl)-2-oxazoline
  • Biocompatible Materials
  • Immunologic Factors
  • Interleukin-1alpha
  • Interleukin-6
  • Oxazoles
  • Polyamines
  • Reactive Oxygen Species
  • Tumor Necrosis Factor-alpha
  • poly(2-ethyl-2-oxazoline)
  • 2-ethyl-2-oxazoline