Mechanotransduction describes the cellular process by which mechanical stimuli are translated into intracellular adaptive responses through biochemical signals. Current research has begun to focus on the once-forgotten organelle, the primary cilia, in this mechanotransduction process. Primary cilia are found on almost every cell type, with a functional role in transducing mechanical and extracellular signals towards intracellular responses through the ciliary extension into the extracellular space. In this regard, the modulation of intracellular calcium signaling by various mechanical stimuli has generated an assortment of attractive models to understand this mechanotransduction process.