Elevated HIF-1α expression of acute myelogenous leukemia stem cells in the endosteal hypoxic zone may be a cause of minimal residual disease in bone marrow after chemotherapy

Leuk Res. 2012 Jun;36(6):e122-4. doi: 10.1016/j.leukres.2012.02.028. Epub 2012 Mar 22.

Authors

T Matsunaga, O Imataki, E Torii, T Kameda, K Shide, H Shimoda, A Kamiunten, M Sekine, Y Taniguchi, S Yamamoto, T Hidaka, K Katayose, Y Kubuki, H Dobashi, S Bandoh, H Ohnishi, F Fukai, K Shimoda

PMID: 22444690
DOI: 10.1016/j.leukres.2012.02.028

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Bone Marrow / metabolism*
Bone Marrow / pathology
Bone and Bones / metabolism
Bone and Bones / pathology
Cell Hypoxia / genetics
Cell Hypoxia / physiology
Cell Line, Tumor
Gene Expression Regulation, Leukemic
HL-60 Cells
Humans
Hypoxia-Inducible Factor 1, alpha Subunit / genetics*
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
K562 Cells
Leukemia, Myeloid, Acute / drug therapy
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / metabolism
Leukemia, Myeloid, Acute / pathology*
Mice
Neoplasm, Residual / etiology
Neoplasm, Residual / genetics
Neoplasm, Residual / metabolism
Neoplastic Stem Cells / metabolism*
Neoplastic Stem Cells / pathology
U937 Cells
Up-Regulation
Xenograft Model Antitumor Assays

Substances

HIF1A protein, human
Hypoxia-Inducible Factor 1, alpha Subunit