Synthesis of [(4-chloro-5H-1,2,3-dithiazol-5-ylidene)amino]azines

Molecules. 2011;16(11):8992-9002. doi: 10.3390/molecules16118992.

Abstract

The reactions of 2-, 3- and 4-aminopyridines with 4,5-dichloro-1,2,3-dithiazolium chloride (Appel salt) 4 to give N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)pyridin-X-amines 1a (X = 2), 1g (X = 3) and 1k (X = 4) were optimized with respect to base, temperature and reaction time. Based on these conditions a total of thirteen [(dithiazolylidene)amino]azines 1a-m were prepared and fully characterized.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminopyridines / chemistry*
  • Chemical Phenomena
  • Hydrazines / chemical synthesis*
  • Hydrazines / chemistry
  • Molecular Structure
  • Temperature
  • Thiazoles / chemical synthesis*
  • Thiazoles / chemistry

Substances

  • 4,5-dichloro-1,2,3-dithiazolium chloride
  • Aminopyridines
  • Hydrazines
  • Thiazoles