Case of fatal congenital toxoplasmosis associated with I/III recombinant genotype

S Boughattas; R Ben-Abdallah; E Siala; O Souissi; R Maatoug; K Aoun; A Bouratbine

Case of fatal congenital toxoplasmosis associated with I/III recombinant genotype

Trop Biomed. 2011 Dec;28(3):615-9.

Authors

S Boughattas¹, R Ben-Abdallah, E Siala, O Souissi, R Maatoug, K Aoun, A Bouratbine

Affiliation

¹ Laboratoire de Recherche 05SP03, Laboratoire de Parasitologie Clinique, Institut Pasteur Tunis, 13 Place Pasteur, BP74, 1002 Tunis Belvédère, Tunisia.

PMID: 22433891

Abstract

We report a case of fatal congenital toxoplasmosis case in Tunis (North of Tunisia) associated with I/III recombinant genotype. The Toxoplasma gondii strain was isolated from placenta and characterized molecularly by a multilocus typing (3'SAG2, 5'SAG2, SAG3, AK69, APICO, and UPRT1) and a sulfadiazine resistance mutation analysis. The isolate was shown to be a wild drug sensitive I/III recombinant strain.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antiprotozoal Agents / pharmacology
DNA, Protozoan / genetics
Female
Genotype
Humans
Infant, Newborn
Multilocus Sequence Typing
Parasitic Sensitivity Tests
Placenta / parasitology
Pregnancy
Recombination, Genetic*
Sulfadiazine / pharmacology
Toxoplasma / classification*
Toxoplasma / genetics*
Toxoplasma / isolation & purification
Toxoplasmosis, Congenital / diagnosis*
Toxoplasmosis, Congenital / parasitology*
Tunisia

Substances

Antiprotozoal Agents
DNA, Protozoan
Sulfadiazine