Most adult smokers began smoking as teenagers, and an estimated 6.4 million young people will eventually suffer premature mortality and/or diminished quality of life as a result of smoking-related diseases. Most teens who smoke want to stop but fail within a month of trying to quit independently. Reaching teens with effective treatments for smoking cessation is essential to their current and future health. This article highlights evidence-based interventions and provides practice recommendations to address adolescent smoking. These include behavioral approaches and initial research regarding pharmacotherapy as well as strategies for individual patient encounters, practice management, and public advocacy.