1,2-Bis[(3,6,9-trimethyl-3,12-ep-oxy-3,4,5,5a,6,7,8,8a,9,10,12,12a-dodeca-hydro-pyrano[4,3-j][1,2]benzodioxepin-4-yl)-oxy]ethane

Acta Crystallogr Sect E Struct Rep Online. 2012 Mar 1;68(Pt 3):o661. doi: 10.1107/S1600536812005089. Epub 2012 Feb 10.

Abstract

The title compound, C(32)H(50)O(10), prepared from a mixture of α- and β-dihydro-artemisinin, has two β-arteether moieties linked via an -OCH(2)CH(2)O- bridge, so that the mol-ecule is symmetric about the bridge. Each asymmetric unit contains a β-arteether moiety and an -OCH(2) group, which is only one-half of the mol-ecule. The endo-peroxide bridges of the parent compounds have been retained in each half of the diol-bridged dimer. The rings exhibit chair and twist-boat conformations.