On-chip stochastic resonance of ion channel systems with variable internal noise

Eric Stava; Siyoung Choi; Hyun-Seok Kim; Robert H Blick

doi:10.1109/TNB.2012.2188539

On-chip stochastic resonance of ion channel systems with variable internal noise

IEEE Trans Nanobioscience. 2012 Jun;11(2):169-75. doi: 10.1109/TNB.2012.2188539. Epub 2012 Mar 9.

Authors

Eric Stava¹, Siyoung Choi, Hyun-Seok Kim, Robert H Blick

Affiliation

¹ Institut für Angewandte Physik und Zentrum für Mikrostrukturforschung, Universität Hamburg, 20355 Hamburg, Germany. estava@physnet.uni-hamburg.de

PMID: 22411054
DOI: 10.1109/TNB.2012.2188539

Abstract

We induced stochastic resonance in planar lipid bilayer systems with alamethicin ion channels, and varied alamethicin concentration, membrane area, and applied voltage. We found that membrane-induced microphonic noise significantly affects the signature of stochastic resonance, and that this noise can be used to optimize ion channel-based biosensors.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Alamethicin / metabolism
Biosensing Techniques / methods*
Electric Impedance
Ion Channels / chemistry*
Lab-On-A-Chip Devices
Lipid Bilayers / chemistry
Models, Theoretical
Signal-To-Noise Ratio
Stochastic Processes*

Substances

Ion Channels
Lipid Bilayers
Alamethicin