Results of the 2nd scientific workshop of the ECCO (III): basic mechanisms of intestinal healing

J Crohns Colitis. 2012 Apr;6(3):373-85. doi: 10.1016/j.crohns.2011.11.009. Epub 2011 Dec 11.

Abstract

The second scientific workshop of the European Crohn's and Colitis Organization (ECCO) focused on the relevance of intestinal healing for the disease course of inflammatory bowel disease (IBD). The objective was to better understand basic mechanisms, markers for disease prediction, detection and monitoring of intestinal healing, impact of intestinal healing on the disease course of IBD as well as therapeutic strategies. The results of this workshop are presented in four separate manuscripts. This section describes basic mechanisms of intestinal healing, identifies open questions in the field and provides a framework for future studies.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / pharmacology
  • Anti-Bacterial Agents / pharmacology
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Antibodies, Monoclonal / pharmacology
  • Azathioprine / pharmacology
  • Butyric Acid / pharmacology
  • Colitis, Ulcerative / genetics
  • Colitis, Ulcerative / physiopathology*
  • Crohn Disease / genetics
  • Crohn Disease / physiopathology*
  • Cyclosporine / pharmacology
  • Defensins / physiology
  • Extracellular Matrix / physiology
  • Humans
  • Immunosuppressive Agents / pharmacology
  • Infliximab
  • Intestinal Mucosa / pathology*
  • Intestinal Mucosa / physiopathology*
  • Leptin / physiology
  • Matrix Metalloproteinases / physiology
  • Mesalamine / pharmacology
  • Paneth Cells / physiology
  • Probiotics / pharmacology
  • Reactive Nitrogen Species / physiology
  • Reactive Oxygen Species / metabolism
  • Sulfasalazine / pharmacology
  • Tumor Necrosis Factor-alpha / physiology
  • Wound Healing / drug effects*
  • Wound Healing / physiology*

Substances

  • Adrenal Cortex Hormones
  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antibodies, Monoclonal
  • Defensins
  • Immunosuppressive Agents
  • Leptin
  • Reactive Nitrogen Species
  • Reactive Oxygen Species
  • Tumor Necrosis Factor-alpha
  • Butyric Acid
  • Sulfasalazine
  • Mesalamine
  • Cyclosporine
  • Infliximab
  • Matrix Metalloproteinases
  • Azathioprine