Abstract
Anti-diabetic capacity of Curcuma longa volatile oil in terms of its ability to inhibit glucosidase activities was evaluated. Turmeric volatile oils inhibited glucosidase enzymes more effectively than the reference standard drug acarbose. Drying of rhizomes was found to enhance α-glucosidase (IC₅₀ = 1.32-0.38 μg/ml) and α-amylase (IC₅₀ = 64.7-34.3 μg/ml) inhibitory capacities of volatile oils. Ar-Turmerone, the major volatile component in the rhizome also showed potent α-glucosidase (IC₅₀ = 0.28 μg) and α-amylase (IC₅₀ = 24.5 μg) inhibition.
MeSH terms
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Acarbose / pharmacology
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Curcuma / chemistry*
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Diabetes Mellitus, Type 2 / drug therapy*
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Diabetes Mellitus, Type 2 / enzymology
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Diabetes Mellitus, Type 2 / metabolism
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Ethnopharmacology
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Glycoside Hydrolase Inhibitors*
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Hot Temperature
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / pharmacology*
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India
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Ketones / analysis
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Ketones / isolation & purification
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Ketones / pharmacology
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Kinetics
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Medicine, Ayurvedic
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Oils, Volatile / chemistry
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Oils, Volatile / pharmacology*
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Rhizome / chemistry
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Sesquiterpenes / analysis
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology
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alpha-Amylases / antagonists & inhibitors*
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alpha-Amylases / metabolism
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alpha-Glucosidases / metabolism
Substances
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Enzyme Inhibitors
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Glycoside Hydrolase Inhibitors
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Hypoglycemic Agents
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Ketones
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Oils, Volatile
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Sesquiterpenes
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ar-turmerone
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alpha-Amylases
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alpha-Glucosidases
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Acarbose