Drug trapping and delivery for Alzheimer's diagnosis

Artif Cells Blood Substit Immobil Biotechnol. 2012 Oct;40(5):303-8. doi: 10.3109/10731199.2012.657203. Epub 2012 Mar 2.

Abstract

In this investigation, a new design based on a PANDA ring resonator as an optical trapping tool for tangle protein, molecular motor storage, and delivery is proposed. The optical vortices are generated and the trapping mechanism is controlled in the same way as the conventional optical tweezers. The trapping force is produced by a combination of the gradient field and scattering photons. The required molecular volume is trapped and moved dynamically within the molecular network. The tangle protein and molecular motor can be transported and delivered to the required destinations for Alzheimer's diagnosis by molecular buffer and bus network.

MeSH terms

  • Alzheimer Disease / diagnosis*
  • Amyloid beta-Peptides / chemistry
  • Amyloid beta-Peptides / metabolism*
  • Axons / chemistry
  • Axons / metabolism*
  • Buffers
  • Electron Spin Resonance Spectroscopy
  • Humans
  • Microtubules / chemistry
  • Microtubules / metabolism*
  • Molecular Motor Proteins / chemistry
  • Molecular Motor Proteins / metabolism*
  • Neurofibrillary Tangles / metabolism*
  • Optical Tweezers*
  • Protein Transport
  • tau Proteins / chemistry
  • tau Proteins / metabolism*

Substances

  • Amyloid beta-Peptides
  • Buffers
  • Molecular Motor Proteins
  • tau Proteins