Abstract
A combination of MACOS scale-out and ROMP-derived oligomeric triazole phosphates (OTP(n)) have been successfully utilized for the preparation of a 106-member library of triazole containing benzothiaoxazepine-1,1-dioxides. This report demonstrates the utilization of a suite of soluble OTP(n) reagents for facile (triazolyl)methylation of 10 MACOS-derived sultam scaffolds in purification-free process for parallel synthesis of small molecule collections for HTS.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Benzothiadiazines / chemical synthesis*
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Benzothiadiazines / chemistry
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Combinatorial Chemistry Techniques
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Methylation
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Microwaves*
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Molecular Structure
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Oxides / chemical synthesis*
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Oxides / chemistry
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Phosphates / chemistry*
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Small Molecule Libraries / chemical synthesis*
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Small Molecule Libraries / chemistry
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Stereoisomerism
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Triazoles / chemistry*
Substances
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Benzothiadiazines
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Oxides
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Phosphates
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Small Molecule Libraries
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Triazoles