Abstract
Three new monoterpene glucosides, ziziphoroside A (1), B (2), and C (3), together with fifteen known compounds were isolated from the whole herb of Z. clinopodioides. The structures of new compounds were determined primarily from 1D-, 2D-NMR and circular dichroism (CD) spectroscopic analyses. The isolated compounds were evaluated for their inhibitory activity against nitric oxide (NO) production by lipopolysaccharide (LPS) and interferon (IFN)-γ activated macrophages, RAW 264.7. Shizonepetoside A (8) and flavones (11, 12, 13) showed potent inhibitory activity against NO production.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line
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Circular Dichroism / methods
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Flavones / chemistry
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Flavones / isolation & purification
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Flavones / pharmacology
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Glucosides / chemistry*
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Glucosides / isolation & purification
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Glucosides / pharmacology
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Interferon-gamma / pharmacology
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Lamiaceae / chemistry*
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects
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Magnetic Resonance Imaging / methods
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Mice
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Monoterpenes / chemistry*
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Monoterpenes / isolation & purification
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Monoterpenes / pharmacology
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Nitric Oxide / antagonists & inhibitors
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plants, Medicinal / chemistry
Substances
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Flavones
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Glucosides
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Lipopolysaccharides
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Monoterpenes
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Plant Extracts
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Nitric Oxide
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Interferon-gamma