Monoterpene glucosides from Ziziphora clinopodioides (Labiatae)

Chem Pharm Bull (Tokyo). 2012;60(3):397-401. doi: 10.1248/cpb.60.397.

Abstract

Three new monoterpene glucosides, ziziphoroside A (1), B (2), and C (3), together with fifteen known compounds were isolated from the whole herb of Z. clinopodioides. The structures of new compounds were determined primarily from 1D-, 2D-NMR and circular dichroism (CD) spectroscopic analyses. The isolated compounds were evaluated for their inhibitory activity against nitric oxide (NO) production by lipopolysaccharide (LPS) and interferon (IFN)-γ activated macrophages, RAW 264.7. Shizonepetoside A (8) and flavones (11, 12, 13) showed potent inhibitory activity against NO production.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Circular Dichroism / methods
  • Flavones / chemistry
  • Flavones / isolation & purification
  • Flavones / pharmacology
  • Glucosides / chemistry*
  • Glucosides / isolation & purification
  • Glucosides / pharmacology
  • Interferon-gamma / pharmacology
  • Lamiaceae / chemistry*
  • Lipopolysaccharides / pharmacology
  • Macrophages / drug effects
  • Magnetic Resonance Imaging / methods
  • Mice
  • Monoterpenes / chemistry*
  • Monoterpenes / isolation & purification
  • Monoterpenes / pharmacology
  • Nitric Oxide / antagonists & inhibitors
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Plants, Medicinal / chemistry

Substances

  • Flavones
  • Glucosides
  • Lipopolysaccharides
  • Monoterpenes
  • Plant Extracts
  • Nitric Oxide
  • Interferon-gamma