Abstract
In vitro anti-allergic screening of medicinal herbal extracts revealed that the EtOAc extract of the rhizoma of Kadsura coccinea inhibited nitric oxide (NO) production in a lipopolysaccharide and recombinant mouse interferon-γ activated murine macrophage-like cell line, RAW264.7. Further fractionation of the EtOAc extract led to the isolation of two new dibenzocyclooctadiene lignans kadsuralignan G (1) and kadsuralignan L (2), and three known analog compounds. The absolute stereostructures were established by circular dichroism spectra. Both 1 and 2 showed moderate NO production inhibitory activities.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Allergic Agents / chemistry
-
Anti-Allergic Agents / isolation & purification*
-
Anti-Allergic Agents / pharmacology
-
Circular Dichroism
-
Cyclooctanes / chemistry
-
Cyclooctanes / isolation & purification*
-
Cyclooctanes / pharmacology
-
Kadsura / chemistry*
-
Lignans / chemistry
-
Lignans / isolation & purification*
-
Lignans / pharmacology
-
Lipopolysaccharides / pharmacology
-
Macrophages / drug effects
-
Mice
-
Molecular Structure
-
Nitric Oxide / biosynthesis
-
Rhizome / chemistry
Substances
-
Anti-Allergic Agents
-
Cyclooctanes
-
Lignans
-
Lipopolysaccharides
-
dibenzocyclooctadiene lignan
-
kadsuralignan G
-
kadsuralignan L
-
Nitric Oxide