Abstract
Ten new carbazole alkaloids, claulansines A-J (1-10), and seven known analogues (11-17) were isolated from the stems of Clausena lansium. Their structures were established on the basis of extensive spectroscopic analyses, and their absolute configurations were determined by CD experiments and computational methods. Screening results indicated that compounds 1, 6, 8-10, 13, 14, and 17 showed selective neuroprotective effects at the concentration of 10 μM.
© 2012 American Chemical Society and American Society of Pharmacognosy
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Carbazoles / chemistry
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Carbazoles / isolation & purification*
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Carbazoles / pharmacology
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Clausena / chemistry*
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Dose-Response Relationship, Drug
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Molecular Structure
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / isolation & purification*
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Neuroprotective Agents / pharmacology
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Nuclear Magnetic Resonance, Biomolecular
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PC12 Cells
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Plant Stems / chemistry
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Rats
Substances
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Alkaloids
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Carbazoles
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Drugs, Chinese Herbal
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Neuroprotective Agents