Episodes of population loss and cultural change, including the famous Classic Collapse, punctuated the long course of Maya civilization. In many cases, these downturns in the fortunes of individual sites and entire regions included significant environmental components such as droughts or anthropogenic environmental degradation. Some afflicted areas remained depopulated for long periods, whereas others recovered more quickly. We examine the dynamics of growth and decline in several areas in the Maya Lowlands in terms of both environmental and cultural resilience and with a focus on downturns that occurred in the Terminal Preclassic (second century Common Era) and Terminal Classic (9th and 10th centuries CE) periods. This examination of available data indicates that the elevated interior areas of the Yucatán Peninsula were more susceptible to system collapse and less suitable for resilient recovery than adjacent lower-lying areas.