Abstract
An efficient one-pot synthesis of novel sugar based dispirooxindolo-pyrrolidines/pyrrolizidines has been accomplished by a [3+2]-cycloaddition. This method utilizes an azomethine ylide derived from isatin and sarcosine/l-proline, with an ether linked α-,β-unsaturated-β-C-glycosidic ketones as the dipolarophile. All these sugar-based heterocyclics were characterized by NMR ((1)H and (13)C) and elemental analysis. Antimicrobial studies of sugar based dispiroheterocyclic compound 10 shows excellent activity against different microbes.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Azo Compounds / chemistry*
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Bacteria / drug effects
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Ethers / chemistry*
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Glycosides / chemistry*
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Humans
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Indoles / chemistry*
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Ketones / chemistry
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Oxindoles
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Pyrrolidines / chemical synthesis*
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Pyrrolidines / chemistry*
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Pyrrolidines / pharmacology
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Stereoisomerism
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Substrate Specificity
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Thiosemicarbazones / chemistry*
Substances
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Anti-Bacterial Agents
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Azo Compounds
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Ethers
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Glycosides
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Indoles
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Ketones
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Oxindoles
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Pyrrolidines
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Thiosemicarbazones
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azomethine
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2-oxindole