Abstract
In the present study the synthesis of new Linezolid-like molecules has been achieved by substitution of the oxazolidinone central heterocyclic moiety with a 1,2,4-oxadiazole ring. Two series of 1,2,4-oxadiazoles, bearing different side-chains and containing a varying number of fluorine atoms, were synthesized and preliminarily tested for biological activity against some Gram-positive and Gram-negative bacteria using Linezolid and Ceftriaxone as reference drugs.
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
Publication types
-
Comparative Study
-
Evaluation Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acetamides / chemistry*
-
Acetamides / pharmacology
-
Anti-Bacterial Agents / chemical synthesis*
-
Anti-Bacterial Agents / pharmacology*
-
Bacteria / drug effects*
-
Ceftriaxone / pharmacology
-
Linezolid
-
Microbial Sensitivity Tests
-
Molecular Structure
-
Oxazolidinones / chemical synthesis*
-
Oxazolidinones / chemistry
-
Oxazolidinones / pharmacology*
-
Structure-Activity Relationship
Substances
-
Acetamides
-
Anti-Bacterial Agents
-
Oxazolidinones
-
Ceftriaxone
-
Linezolid