Cembranoids from the Dongsha Atoll soft coral Lobophytum crassum

Shih-Tseng Lin; Shang-Kwei Wang; Chang-Yih Duh

doi:10.3390/md9122705

Cembranoids from the Dongsha Atoll soft coral Lobophytum crassum

Mar Drugs. 2011 Dec;9(12):2705-2716. doi: 10.3390/md9122705. Epub 2011 Dec 15.

Authors

Shih-Tseng Lin¹, Shang-Kwei Wang², Chang-Yih Duh^{1

3}

Affiliations

¹ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
² Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
³ Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.

Abstract

Chemical investigation of the Dongsha Atoll soft coral Lobophytum crassum has afforded four new cembranoids, crassumols A-C (1-3) and 13-acetoxysarcophytoxide (4). The structures of these isolated compounds were elucidated by extensive NMR and HRESIMS experiments. The cytotoxicity and anti-HCMV (Human cytomegalovirus) activities of 1-4 were evaluated in vitro. Compound 4 exhibited cytotoxicity against A-549 (human lung carcinoma) cell line with an ED(50) of 3.6 μg/mL.

Keywords: Lobophytum crassum; cytotoxicity; soft coral.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Cell Line, Tumor
Diterpenes / chemistry
Diterpenes / isolation & purification*
Diterpenes / pharmacology
HT29 Cells
Humans
Leukemia P388 / drug therapy
Magnetic Resonance Spectroscopy
Mice

Substances

Diterpenes