Abstract
Quaternary salts of several 2-alkylthio substituted derivatives of thieno [2,3-d]pyrimidin-4-one and 5H-pyrimido [5,4-b]indol-4-one with a basic group in position 2 of the alkyl chain were synthesized and screened for potential spasmolytic activity. These substances were prepared by condensation of the corresponding mercapto compounds with a 2-chloroalkyltertiary amine. The tertiary bases were quaternized with methyl iodide. Among the assayed compounds, the thieno [2-3-d]pyrimidin-4-one derivatives displayed a potent spasmolytic activity in the in vitro and in vivo assays.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aorta, Thoracic / drug effects
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Charcoal / pharmacology
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Chemical Phenomena
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Chemistry
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Guinea Pigs
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Ileum / drug effects
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In Vitro Techniques
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Indoles / chemical synthesis*
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Indoles / pharmacology
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Indoles / toxicity
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Male
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Mice
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Muscle Contraction / drug effects
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Muscle, Smooth / drug effects
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Muscle, Smooth, Vascular / drug effects
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Parasympatholytics / chemical synthesis*
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Pyrimidines / chemical synthesis*
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Pyrimidines / pharmacology
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Pyrimidines / toxicity
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Pyrimidinones / chemical synthesis*
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Pyrimidinones / pharmacology
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Pyrimidinones / toxicity
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Rabbits
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Thiophenes / chemical synthesis*
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Thiophenes / pharmacology
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Thiophenes / toxicity
Substances
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Indoles
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Parasympatholytics
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Pyrimidines
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Pyrimidinones
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Thiophenes
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Charcoal