Abstract
Prolonged use of glucocorticoids is associated with an increase in cardiovascular morbidity and mortality: hypertension and atheroma mainly. Severe cardiovascular complications of pulse corticosteroids are related to underlying comobidities and require some precautions. There are probably individual factors of complications associated with polymorphisms of the glucocorticoid receptor. Without clearly established recommendations concerning prevention of cardiovascular risk, screening and treatment of risk factors during treatment is the best prevention possible. Screening and treatment of cardiovascular complications require a just prescription and appropriate surveillance.
Copyright © 2012. Published by Elsevier Masson SAS.
MeSH terms
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Adrenal Cortex Hormones / adverse effects*
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Adrenal Cortex Hormones / therapeutic use
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Anti-Inflammatory Agents / adverse effects*
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Anti-Inflammatory Agents / therapeutic use
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Cardiovascular Diseases / chemically induced*
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Cardiovascular Diseases / mortality
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Cardiovascular Diseases / prevention & control
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Drug Administration Schedule
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Humans
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Hypertension / chemically induced
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Hypertension / mortality
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Hypertension / prevention & control
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Immunosuppressive Agents / adverse effects*
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Immunosuppressive Agents / therapeutic use
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Long-Term Care
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Plaque, Atherosclerotic / chemically induced
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Plaque, Atherosclerotic / mortality
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Plaque, Atherosclerotic / prevention & control
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Pulse Therapy, Drug
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Risk Factors
Substances
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Adrenal Cortex Hormones
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Anti-Inflammatory Agents
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Immunosuppressive Agents