Causes and consequences of damage to mitochondria : morphological aspects

J Miquel; C Bertoni-Freddari

doi:10.1385/1-59259-070-5:221

Causes and consequences of damage to mitochondria : morphological aspects

Methods Mol Med. 2000:38:221-35. doi: 10.1385/1-59259-070-5:221.

Authors

J Miquel¹, C Bertoni-Freddari

Affiliation

¹ Institute of Neurosciences, Faculty of Medicine, Miguel Hernandez University, San Juan, Alicante, Spain.

PMID: 22351278
DOI: 10.1385/1-59259-070-5:221

Abstract

In recent years the role played by mitochondria in cellular aging has become the focus of intensive research. The concept that these energy-producing organelles are involved in aging derives from the views of Harman (1) and Gerschman (2) linking senescence to the damaging effects of free radicals, especially those released in the mitochondrial respiratory chain.