Glycolic acid-g-chitosan-Pt-Fe3O4 nanoparticles nanohybrid scaffold for tissue engineering and drug delivery

Abstract

This work presents the potential use of novel nanohybrid based on chitosan-g-glycolic acid and Pt-Fe(3)O(4) composite nanoparticles in drug delivery and tissue engineering applications. The Pt-Fe(3)O(4) hybrid nanoparticles are prepared by thermal decomposition of H(2)PtCl(6)·6H(2)O at high temperature. The prepared nanoparticles were characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and physical property measurement system (PPMS). Next step of this paper reveals the potential use of novel hybrids of chitosan-g-glycolic acid and Pt-Fe(3)O(4) hybrid nanoparticles in controlled drug delivery applications. The drug loaded nanohybrid scaffold is prepared by freeze drying of grafted polymer solution. Drug loading and grafting of chitosan was characterized by Fourier transform infrared spectroscopy (FTIR). The cell proliferation also shows that the prepared nanohybrids are biocompatible. The nanohybrid was found to be stable regardless of pH of the medium. Therefore, Pt-Fe(3)O(4) hybrid nanoparticles are viable additive for sustained drug delivery and it could be applied in the field of biomedical.